23andMe

Clinical exome reports, saliva genotyping, two blood panels a year and clinician support.

Visit 23andme.org

Price

$508.99

Then $199/yr

Included

Genotyping + clinical exome reports

Two blood panels/year; smaller follow-up

Getting tested

Mail-in kit

Plus lab visit at Quest

What’s included

Included

Cancer Included

9 reports, including Risk score: Breast Cancer (available for females only); Risk score: Colorectal Cancer; Hereditary Prostate Cancer (HOXB13-Related); Risk score: Prostate Cancer (available for males only); Risk score: Skin Cancer (Basal and Squamous Cell Carcinomas); …

Heart and blood vessels Included

9 reports, including Risk score: Atrial Fibrillation; Risk score: Coronary Artery Disease; Risk score: HDL Cholesterol; Risk score: High Blood Pressure; Risk score: LDL Cholesterol; …; Inherited clotting disorders (such as Factor V Leiden and prothrombin) (Hereditary Thrombophilia; Other Hereditary Conditions: 2 genes (F2, F5))

Brain health Included

Alzheimer's (APOE) (Late-Onset Alzheimer's Disease; Hereditary Neurological Disease Report: APOE); Parkinson's disease (Parkinson's Disease; Hereditary Neurological Disease Report: 2 genes (GBA, LRRK2))

Metabolic health Included

Type 2 diabetes (Risk score: Type 2 Diabetes); Celiac disease (Celiac Disease); Hereditary hemochromatosis (Hereditary Hemochromatosis (HFE-Related); Other Hereditary Conditions: HFE)

Carrier screening Partial

46 reports, including ARSACS; Agenesis of the Corpus Callosum with Peripheral Neuropathy; Autosomal Recessive Polycystic Kidney Disease; Beta Thalassemia and Related Hemoglobinopathies; Bloom Syndrome; …

Medication response Included

CYP2C19 Drug Metabolism; DPYD Drug Metabolism; SLCO1B1 Drug Transport; GLP-1 Medications: Weight Loss and Nausea

Scope
Selected reports do not constitute a broad diagnostic rare-disease workup. No purchased oral-microbiome report was listed.
Baseline blood panel
Lipid panel, comprehensive metabolic panel, CBC, HbA1c, TSH, Lp(a) and ApoB.
Six-month blood panel
Lipid panel, comprehensive metabolic panel, CBC and HbA1c.

Results

Report

Celiac disease report

A genetic result with an explanation and guidance on using the report.

Official sample
Celiac disease report
Celiac disease report
Results
Genetic reports in your account, with ancestry tools and the health reports in your selected plan.
Access
WebiPhoneAndroid
Download
Genotype TXT download in ZIP; raw sequencing-data download is also available.
Timing
Genotyping: about 4–6 weeks after registration/sample return; exome: another 7–12 weeks after genotyping results.

Help

Clinician review

Included

A clinician interprets your exome and blood-test results.

Live consultation

Included

A physician or nurse practitioner discusses your exome results in an annual appointment lasting about 30 minutes.

Messaging about results

Included

You can message a clinician without a usage limit after your results arrive.

AI assistant

Included

DaNA answers general educational questions without access to your results.

Getting tested

Register the saliva kit in your 23andMe account, collect at home and use the supplied return mailer. Total Health also includes separate Quest blood visits.

Preparing for your test

Saliva preparation
No food, drink, smoking, gum, tooth brushing or mouthwash for 30 minutes before collection.

About 23andMe

23andMe combines ancestry with selected genetic-health reports from a home saliva sample. Premium adds ongoing report access; Total Health goes further with clinical exome reports, partner-lab blood testing and clinician support.

Register your saliva kitReturn your sampleExplore your genetic reports

Reviews

What people praise

Discovering family connections

Customers enjoy finding relatives and exploring their ancestry, including making family connections or filling in parts of their background they did not previously know.

A simple testing process

Positive reviews describe a manageable kit process and results that are easy to browse, making it straightforward to start exploring their ancestry and traits.

More to explore over time

Reviewers enjoy returning to genetic updates and new ancestry details, finding that reports and family connections give them more to explore after their first results.

What people complain about

More features behind subscriptions

Some customers dislike repeated upgrade prompts or discovering that tools they expected to use, including previously available features, now require another payment.

Login and account support problems

Customers describe password or account-access problems that keep them from their results, with support exchanges that do not always lead to a prompt resolution.

Family-tree tools can be limiting

Some ancestry customers find family-tree tools confusing or limited, struggling to understand how DNA matches connect or wanting better ways to explore those relationships.

Things to know

  • Cancel renewal before the next billing period.

    Access continues until the paid period ends. Basic reports remain after premium access ends; clinical medical records remain accessible.

  • The selected plan renews annually.

    The first year is included in the purchase; renewal and clinical-service terms follow the selected plan.

  • Research and matching are separate choices.

    Research participation, relative sharing and sample storage are optional choices. Deletion has legal record-retention exceptions.

  • Age and state rules depend on the tier.

    Total Health requires eligible partner-lab visits as well as the registered saliva sample.

Compare providers

Alternatives

FAQs

How does Total Health differ from Premium?

Premium uses selected-variant genotyping for ancestry and genetic-health reports. Total Health adds clinical exome reports, blood testing and clinician support.

Does this sequence my whole genome?

No. Premium uses selected-variant genotyping. Total adds exome sequencing with a defined clinical report set, not whole-genome sequencing.

Can I download my DNA data?

Download your genotype data as a TXT file in ZIP. Raw sequencing-data download is also available.

Can I get a refund?

For unused direct-purchase kits, request within 30 days of order before sending saliva, and return the kit within 30 days of the request. Deductions may apply; partial membership periods are not refunded.

Are both blood panels the same?

No. Baseline includes lipid panel, CMP, CBC, HbA1c, TSH, Lp(a) and ApoB. Follow-up lists lipid panel, CMP, CBC and HbA1c.