About Nucleus Genomics
Nucleus sequences a home cheek-swab sample for inherited-condition, carrier, common-risk and trait reports. Health and Preview are report areas for one person, with genome-file downloads and renewing membership. A genetic-counselor appointment is an optional extra.
Complete registration and health questionsReturn cheek swabsExplore reports and genome files
Offering
Nucleus Health + Preview
$538
initial purchase
Then $39/year
Whole-genome health risks and carrier screening
One 30× average kit includes Health and Preview
At-home 30× average whole-genome sequencing with inherited-condition, carrier, common-risk and trait reports.
What’s included
Included
64 reports, including Risk score: Breast cancer; Risk score: Colorectal cancer; Risk score: Male breast cancer; Risk score: Ovarian cancer; Risk score: Prostate cancer; …
58 reports, including Risk score: Coronary artery disease; Risk score: Hypertension; Familial hypercholesterolemia 2; Hypercholesterolemia 1; Familial hypercholesterolemia 3; …; Inherited clotting disorders (such as Factor V Leiden and prothrombin) (Thrombophilia 3 due to protein C deficiency, autosomal dominant; Thrombophilia 3 due to protein C deficiency, autosomal recessive; Thrombophilia 5 due to protein S deficiency, autosomal recessive)
Alzheimer's (APOE) (Risk score: Alzheimer's disease); Parkinson's disease (12 reports, including Risk score: Parkinson's disease; Parkinson's disease 22; Parkinson's disease 8; Parkinson's disease 1 and 4; VPS35-related Parkinson's disease; …)
Celiac disease (Risk score: Celiac disease); Type 2 diabetes (7 reports, including Risk score: Type 2 diabetes; Type 2 diabetes, maturity-onset diabetes of the young (MODY) type 12, and pulmonary arterial hypertension; DNAJC3-related type 2 diabetes; GPD2-related type 2 diabetes; Type 2 diabetes and maturity-onset diabetes of the young (MODY) type 13; …); Hereditary hemochromatosis (Hemochromatosis, type 2B; Hemochromatosis, type 2A; Hemochromatosis, type 3; Hemochromatosis)
Nucleus Preview
Malignant hyperthermia susceptibility 1; Malignant hyperthermia susceptibility 5; Warfarin resistance
Not included
- Named inherited reports
- Includes BRCA1/BRCA2, Lynch, familial-heart and carrier reports; a negative result does not rule out every inherited condition or variant.
- Alzheimer’s risk
- Public report gene display names APOE; this does not verify an individual ε4 genotype report or treatment eligibility.
- One person
- Health and Preview are report areas in one kit. Partner/embryo testing requires a separate purchase.
Before you buy
- Instructions
- Follow supplied swab instructions; no specific fasting or medication-stop interval established.
Results
Report
The desktop report groups genetic results and links to individual condition reports.
Member walkthrough- Results
- Health and Preview genetic reports, plus advertised raw genome downloads.
- Download
- Advertised VCF, CRAM, SV, CNV and FASTQ downloads
- Timing
- About 4–6 weeks after laboratory receipt.
Help
Live consultation
Extra feeA SteadyMD genetic counselor discusses your results with you for one hour for $99.
Collection
Collect both cheek swabs for the same person and return them in the supplied tube. New York customers must collect and mail the sample from outside New York.
Reviews
What people complain about
Reports can feel less detailed
Some sequencing customers find the ready-made analysis less informative than expected and turn to their raw files for further exploration, particularly when they want more detailed interpretation.
Stories
Ethan C.
Following an unexpected inherited iron-risk result
Nucleus flagged a high risk of hereditary hemochromatosis for Ethan, a condition he had not heard of before. He followed up, received treatment and reported feeling much better, turning an unexpected genetic finding into a useful next step.
mynucleus.comMichael Hendricks
Planning closer attention to eye health
Michael’s Nucleus results put his macular-degeneration risk into context alongside factors such as age. He said the explanation helped him decide to have more regular eye examinations, giving him a practical way to follow up on the information.
mynucleus.comThings to know
- Approved kit cancellations have a seven-day window.
A cancellation deduction applies; ordinary refunds end after the laboratory receives the sample.
- Membership renews annually.
Personal genetic counseling is an optional extra.
- External health-data research requires opt-in consent.
External PHI research is opt-in; internal validation, service sharing and legal disclosures have separate terms.
- Collect outside New York.
New York customers may receive a kit there but must collect and mail the sample outside the state.
Alternatives
23andMe · Premium Ancestry + Health
Uses selected-variant genotyping and adds ancestry matching, rather than Nucleus whole-genome sequencing.
$208.99
tellmeGen · Advanced DNA Kit
Uses selected variants for health and ancestry instead of Nucleus whole-genome sequencing.
$159.99
Sequencing.com · Comprehensive Health
Another whole-genome option with raw files, a report marketplace and a different continuing-access plan.
$599
24Genetics · All in One
A selected-marker package delivered as PDFs rather than a whole-genome health account.
$299FAQs
What does the first-year purchase include?
One US kit includes the test and required first-year membership, with free US shipping and prepaid return. Membership renews annually; tax is shown at checkout.
Are Health and Preview two people’s tests?
No. One kit includes both report areas for one person. Its two swabs are not two sequencing purchases; a partner needs another kit.
Is genetic counseling included?
No. Optional SteadyMD genetic counseling is $99 for one hour; Embryo and IVF+ have separate support terms.
Can I collect in New York?
A kit may be received in New York, but the sample must be collected and mailed from outside New York. This is a collection/return restriction, not a ban on New York residents.
Can I download my genome?
VCF, CRAM, SV, CNV and FASTQ downloads are advertised. Check access terms before your membership ends.
What if I wait to send the sample?
The laboratory must receive the sample within one year of ordering. Approved kit cancellations have a separate seven-day window.